LABOTEST-BB LT00159528
dinitolmide
CAS: 148-01-6
Molecular Formula: C8H7N3O5
LABOTEST-BB LT00159528 - Names and Identifiers
| Name | dinitolmide |
| Synonyms | ZOALENE Zoalene NITROMID DINITOLMIDE dinitolmide Bornylformiat 3,5-DINITRO TOLUAMIDE 3,5-dinitro-o-toluamid LABOTEST-BB LT00159528 3,5-Dinitro-o-toluamide 2-methyl-3,5-dinitro-benzamid 2-methyl-3,5-dinitrobenzamide AMIDE 3,5-DINITRO-O-TOLUIC ACID |
| CAS | 148-01-6 |
| EINECS | 205-706-4 |
| InChI | InChI=1/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12) |
| InChIKey | ZEFNOZRLAWVAQF-UHFFFAOYSA-N |
LABOTEST-BB LT00159528 - Physico-chemical Properties
| Molecular Formula | C8H7N3O5 |
| Molar Mass | 225.16 |
| Density | 1.5406 (rough estimate) |
| Melting Point | 170-180 °C (lit.) |
| Boling Point | 366.66°C (rough estimate) |
| Flash Point | 2°C |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00131mmHg at 25°C |
| Appearance | White crystal |
| Color | Pale Beige to Light Beige |
| Merck | 13,3297 |
| pKa | 13.74±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.7400 (estimate) |
| MDL | MFCD00072065 |
| Physical and Chemical Properties | Off-white or light yellow-brown powder, odorless, bitter. Melting point 181 °c. Soluble in acetone, ethanol-soluble, insoluble in water. Chicken oral LD50275mg/kg. |
| Use | Used in feed can promote the growth of chicken |
LABOTEST-BB LT00159528 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | XS4200000 |
| HS Code | 29242990 |
LABOTEST-BB LT00159528 - Upstream Downstream Industry
| Raw Materials | Sulfuric acid Thionyl chloride Nitric acid |
LABOTEST-BB LT00159528 - Reference
| Reference Show more | 1. [IF=7.46] Di Shao et al."Selective determination of dinitolmide and toltrazuril by surface-enhanced raman spectroscopy (SERS) using AgNPs as substrate."Sensor Actuat B-Chem. 2020 Mar;307:127644 |
LABOTEST-BB LT00159528 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | dinitrotamide is a nitrophenyl amide compound, which is an anti-coccidiosis drug with both preventive and therapeutic effects. It is effective for a variety of chicken Eimeria, especially for poisoning Eimeria and tender Eimeria. Mainly inhibit the first generation of schizonts, the peak of action is in the second asexual stage of the coccidia The proliferation stage of the schizonts (that is, the 3rd day after infection), and it also has an inhibitory effect on the formation of sporozoites in the oocysts. The coccidia can develop drug resistance to this product, but the production speed is slow, which does not affect the body's immunity to coccidia. The amount of treatment has no obvious adverse effect on chicken development and egg laying. However, long-term high-concentration use of dinitrotamine will cause drug residues and cause potential harm to human health. Announcement No. 235 of the Ministry of Agriculture of China stipulates that the maximum residue limit of dinitrotamine is 3000 and 6000ug/kg in chicken and chicken liver, based on the total amount of parents and metabolites. Fig. 1 is the structural formula of dinitrotamide |
| use | control coccidiosis in chickens and turkeys. In particular, the toxic Eimeria, which is the most pathogenic to the small intestine, has the best effect, but the effect on the heap Eimeria is slightly worse. It also has excellent control effect on turkey small intestine coccidia, and can be used continuously until 16 weeks of age. (2016-01-22) As an anticoccidial drug, it has the best control effect on the poisonous sea Eimel (Ehrlich) in the small intestinal coccidia, and it is also effective for the soft Ehrlich, Borghich and giant Ehrlich. Can be used for chicken feed, the maximum dosage is 125 g/t, and it is forbidden during laying. as an anticoccidial drug, this product has special effects on the prevention and treatment of coccidiosis in livestock and poultry. This product is effective in dosage, without any side effects, non-toxic, stable in performance, and does not decompose when added to feed. In addition to preventing coccidiosis, it can also promote the weight gain of poultry (weight gain rate 13.8%) and improve feed utilization rate. After dissolving in water, this product has a flavor of inducing food for anorexia sick chickens, and the medication effect is excellent. Usage and dosage can be 62g of this product mixed in 1t feed, used for chicken and other poultry, livestock feeding, prevention amount halved; 4g of this product is dissolved in 10kg of water, used for chicken and other poultry, livestock drinking, prevention amount halved; It can be used for chicken feed, the maximum dosage is 62.0 g/t, it is forbidden during laying period, and the drug withdrawal period is 3 days. It can promote the growth of chickens when used in feed |
| drug interaction | is not combined with polyether drugs such as hainanamycin and salinomycin. There are incompatibility with nicarbazine. |
| precautions | 1. the size of dinitrotamine powder particles is the main factor affecting the effect of coccidia, and it should be extremely fine powder in clinical application. 2. This product often causes recurrence of coccidiosis after 5~6 days of drug withdrawal, so continuous medication is required. 3. Broilers are off for 3 days. 4. When the addition amount of feed exceeds 250 mg/kg, the weight gain of chicks can be inhibited if fed continuously for more than 15 days. 5. The laying period of laying hens is prohibited. |
| production method | the synthetic route is similar to vitamin B1 production, see vitamin B1(03002). Using o-methyl acid as raw material, 3, 5-dinitroo-methyl benzoic acid is obtained by nitration, and then chlorinated with dichlorosulfoxide acyl and ammoniated with ammonia to obtain the product. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:07
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Raw Materials for LABOTEST-BB LT00159528